ea0065oc2.1 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019
Russell Georgina
, Kalafatakis Konstantinos
, Thakrar Jamie
, Hudson Elizabeth
, Alim Lina
, Marchant Nicola
, Thirard Russell
, Brooks Jonathan
, Thai Jade
, Harmer Catherine
, Lightman Stafford
Background : Patients with primary adrenal insufficiency (PAI) describe significant impairments in quality of life. Current replacement regimes are non-physiological. Animal studies indicate that pulsatile presentation of endogenous glucocorticoids is critical for normal transcriptional and behavioural responses. Healthy volunteer work also shows that pattern of glucocorticoid presentation alters cognitive and emotional processing.Objective: To assess th...